Additional Study Information: We are doing this research study to learn more about human blood cells called monocytes.Currently, there are several well-documented types of monocytes, each having unique roles in ourimmune system and in heart and vascular diseases. This study will examine the genetic make-up ofmonocytes to identify new and unique subsets across different cardiovascular (CV) risk states, including Type II Diabetes (DM2), tobacco smoking, and high cholesterol. We are seeking to understand if some types of monocytes are more prevalent within specific cardiovascular risk states than others. This may serve to help people with cardiovascular or metabolic disease in the future by understanding precisely which monocyte cell type are involved and developing treatments based on this new knowledge. Our study addresses a major knowledge gap by examining and defining the landscape of human monocyte subpopulations and their relationship to specific cardiovascular risk states. Participants will complete a detailed health questionnaire, brief physical exam (height, weight, blood pressure), and provide blood and urine samples during one visit to Columbia University Medical Center. Compensation of $50 is provided after the visit is completed.