Additional Study Information: This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness ofan investigational drug to learn whether the study drug works in treating a specific disease.Investigational means that the drug is being studied. In this research study, we are looking to compare the effects, good and bad, of the standard of care with the three investigational agent sub-studies to help people with glioblastoma or gliosarcoma cancer including the specific molecular changes in the patients genes and proteins (biomarkers).