Phlebotomy for generating iPS cells
Study of Blood from Individuals with Rheumatoid Arthritis (RA) or Systemic Lupus (SLE)
Sponsor: Internal
Enrolling: Male and Female Patients
Study Length: 1 Days
Clinic Visits: 1
IRB Number: AAAR4878
Contact: Christopher Depender: 212-305-4114 / cd2686@cumc.columbia.edu
Additional Study Information: We invite you to take part in this research study because you have Rheumatoid Arthritis (RA) or Systemic Lupus (SLE). Patients with RA & SLE develop severe heart disease and heart failure much more frequently than healthy people in a way that suggests some component of the immune response that results in rheumatoid arthritis and systemic lupus is responsible for the heart injury. Since it is very difficult to investigate the processes leading to heart injury in a patient we seek to construct a laboratory model of the interaction between the heart cells of a RA/SLE patient and the elements of their immune system that might be responsible for the injury. These experiments take advantage of research showing stem cells present in the circulation can be induced to develop into beating heart muscle cells. Then the induced heart muscle cells are grown together with different types of white cells present in the rheumatoid arthritis patients blood or with antibodies from the blood that are thought to be candidates for mediating this injury, and the heart cells are observed for signs of injury. In this study, we are collecting blood from patients with RA & SLE to establish stem cell lines called "induced pluripotent stem cells". These stem cells can then be used for tissue engineering purposes at labs throughout Columbia University. Because blood also contains immune cells, a second purpose for its collection will be to provide immune cells for studies of immunological rejection of engineered tissues.
This study is closed
Investigator
Robert Winchester, MD
Do You Qualify?
Have you been diagnosed with rheumatoid arthritis (RA) or systemic lupus (SLE)? Yes No
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For more information, please contact:
Christopher Depender
cd2686@cumc.columbia.edu
212-305-4114