Additional Study Information: This study seeks to identify genes increasing the risk of Alzheimer's disease. The Genetic Studies of Alzheimers Disease in Caribbean Hispanics is a research study to find the genes that play a role in Alzheimer's disease (AD), and to learn more about the causes of AD, and how to treat or prevent it. We are currently enrolling individuals with and without memory problems as well as families with two or more members with Alzheimer's disease or memory problems. Family members can can live anywhere in the U.S., Dominican Republic or Puerto Rico. Enrolled participants will undergo cognitive testing, a blood draw in their home and Lumbar puncture (optional) at CUMC. Participants will be reimbursed for their time.