Dr. Goldklang’s main area of research interest is in translational studies investigating the pathogenesis of smoking related lung disease. Her work involves understanding the mechanisms of protease upregulation in lung injury. She is currently working on a project investigating factors that alter MMP-13 expression and activity in lung disease. Moving forward, Dr. Goldklang has received NIH K08 funding to investigate the role of ion channels in smoking related lung disease. A broader understanding of intracellular calcium regulation, through BK channel and ryanodine receptor function, in lung injury is a central focus of this work.