Department Of Substance Abuse
Sandra Comer, PhD

Dr. Sandra Comer is Professor of Neurobiology in the Department of Psychiatry at the College of Physicians and Surgeons of Columbia University, and Research Scientist VI at the New York State Psychiatric Institute. She received her BS at Vanderbilt University and PhD at the University of Michigan for her research on the effects of abused drugs using preclinical models. Dr. Comer’s research focus at Columbia University has been on the clinical development and testing of novel approaches to the treatment of opioid use disorder (OUD), such as the ability of sustained-release medications to alter the subjective and reinforcing effects of opioids. She also has studied sex differences and hormonal influences on responses to pain and opioid medications, and the role of inflammation in opioid-mediated effects. She currently is conducting a large, prospective, longitudinal study to evaluate ways to maximize the effectiveness of naloxone when administered by opioid users to reverse opioid overdose. Another line of research in her laboratory is to examine the comparative abuse liability of several commonly prescribed pain medications using laboratory models of drug self-administration in humans.

Dr. Comer served as a regular member of the National Institutes of Health Biobehavioral Regulation, Learning and Ethology (BRLE) study section and she currently serves on numerous ad hoc NIH grant review committees. She was a voting member of the Institutional Review Board of the New York State Psychiatric Institute and of the Faculty Council of the Faculty of Medicine. For several years, Dr. Comer served as Program Chair of the College on Problems of Drug Dependence, the longest standing scholarly society in the United States that is devoted to issues surrounding substance use disorders. She was also President of CPDD and currently is serving as the Public Policy Officer for CPDD. Dr. Comer recently joined the Expert Advisory Panel on Drug Dependence for the World Health Organization and is the author or co-author of more than 140 papers, chapters, and books addressing several aspects of substance abuse.

Clinical Studies Managed By This Investigator:
Condition Study Title
Opioids [ CLOSED ] Healthy heroin users needed
Addiction [ CLOSED ] Assessing the Abuse Potential of Oxymorphone in Opioid Use Disorder Patients
Opioids Clinical Trials of Multivalent Opioid Vaccine Components
Opioids Understanding the Cognitive Impacts of Opioid Use Disorder and Opioid Overdose
Opioids A Study of LYN-014 in Individuals with Opioid Use Disorder who are Stable on Methadone Therapy