D8488C00001/ CONCERTO: A single arm, open-label, Phase IIb study to assess the efficacy and safety of the combination of cediranib and olaparib tablets in women with recurrent platinum resistant epithelial ovarian cancer, including Fallopian tube and/or primaryperitoneal cancer who do not carry a deleterious or suspected deleterious germline BRCA mutation
Sponsor: |
AstraZeneca |
Enrolling: |
Female Patients Only |
IRB Number: |
AAAR5554 |
U.S. Govt. ID: |
NCT02889900 |
Contact: |
Reena Vattakalam: 212-342-6895 / rmv2110@cumc.columbia.edu |
A single arm, open-label, Phase IIb study to assess the efficacy and safety of the combination of cediranib and olaparib tablets in women with recurrent platinum resistant epithelial ovarian cancer, including Fallopian tube and/or primary peritoneal cancer who do not carry a deleterious or suspected deleterious germline BRCA mutation. The purpose of the study is to see if the combination of two drugs, cediranib and olaparib, is effective and tolerable in patients with ovarian cancer who have received at least 3 prior chemotherapy treatments, including treatment that included either carboplatin or cisplatin, and their disease came back within 6 months of the last dose of chemotherapy that included either cisplatin or carboplatin.
This study is closed
Investigator
Jason Wright, MD
Have you been diagnosed with endometroid, ovarian cancer, fallopian tube or primary peritoneal carcinoma? |
Yes |
No |
Have you been found to have BRCA1 or BRCA2 gene mutations? |
Yes |
No |
Have you had at least 3 previous chemotherapy lines? |
Yes |
No |