Femara (Letrozole) Plus Ribociclib (LEE011) or Placebo as Neo-adjuvant Endocrine Therapy for Women with ER-positive, HER2-negative Early Breast Cancer
Study of Combination of Letrozole Plus Letrozole as Endocrine Therapy for Women with Breast Cancer
Sponsor: Novartis
Enrolling: Female Patients Only
IRB Number: AAAR0658
U.S. Govt. ID: NCT02712723
Contact: Meghna Trivedi MD: 212-305-1945 / mst2134@cumc.columbia.edu
Additional Study Information: The goal of this study is to determine if ribociclib in combination with letrozole as neoadjuvant endocrine therapy increases the proportion of women with PEPI score of 0 at surgery, compared to patients treated with letrozole alone therefore allowing more patients excellent outcomes without chemotherapy. The PEPI score measures the risk of breast cancer returning in women who received endocrine (hormone) therapy before for surgery. This technique uses tumor size, cancers proximity to lymph nodes, hormone receptor status of the cancer, and Ki67 (a cellular protein) blood levels to calculate this risk.
This study is closed
Investigator
Meghna Trivedi, MD
Do You Qualify?
Are you a woman who is 18 years of age or older? Yes No
Do you have invasive breast cancer? Yes No
Are you postmenopausal (had your ovaries removed, no period for 1year, or your hormone levels are in postmenopausal range)? Yes No
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Place Holder




For more information, please contact:
Meghna Trivedi MD
mst2134@cumc.columbia.edu
212-305-1945