A randomized, double-blind, multi-dose, placebo-controlled study to evaluate the efficacy, safety and tolerability of GSK2330672 administration for the treatment of pruritus in patients with primary biliary cholangitis (GLIMMER: GSK triaL of IBAT inhibition with Multi-Dose Measurement for Evaluation of Response)
GLIMMER: Study of Drug in Treatment of Pruritus (Itching) in Patients with Primary Biliary Cholangitis
Sponsor: GlaxoSmithKline
Enrolling: Male and Female Patients
Study Length: 24 Weeks
Clinic Visits: 7
IRB Number: AAAR2207
U.S. Govt. ID: NCT02966834
Contact: Cristina Falo, PhD: 212-305-6758 / cf2427@cumc.columbia.edu
Additional Study Information: The purpose of this study is to test a drug called GSK2330672 that is not yet approved for doctors to prescribe for patients who have a condition called primary biliary cholangitis (PBC) which has caused moderate to severe pruritus, or itching, in parts or all of the body. The objective is to find out if the drug can help to decrease the itchiness that patients are feeling from PBC. This study is about 24 weeks long (about 20 weeks of treatment with GSK2330672 or placebo and about 4 weeks of follow-up without any study treatment). It will look at how people react to GSK2330672 and how the body uses GSK2330672. Participates will need to visit the clinic for 7 study visits to have tests done. Additionally, they will speak on the telephone with a study team member at Week 24 to ask about any changes to their symptoms and treatments as a final Follow-Up to the study. Participants will also be asked to complete questionnaires regarding PBC on an electronic device. In addition to the main study, the study team will also ask patients if they would be willing to participate in two additional optional sub-studies: -Actigraphy Sub-Study -Genetic Substudy
This study is closed
Elizabeth Verna, MD
Do You Qualify?
Do you have primary biliary cholangitis (PBC), a chronic, long-term disease of the liver? Yes No
Do you have moderate to severe pruritis, or itching, in parts or all of your body? Yes No
You may be eligible for this study

Place Holder

For more information, please contact:
Cristina Falo, PhD