Additional Study Information: This study is for patients with tumors that cannot be removed (unresectable) or has spread (metastasized) to a different part of the body. The main purpose of the study is to determine at what dose the study drug is safe and tolerated. The study drug is called ASP8374. The study also wants to see how ASP3874 is processed in the blood. When the safe dose is identified, it will be used to learn if the study treatment causes tumors to shrink in patients. Cancers include: bladder cancer, breast cancer, colon and rectal cancer, liver cancer, lung cancer, lymphoma, skin cancer, pancreatic cancer, sarcomas, and stomach cancer.