A Randomized Phase 2 Trial of Cediranib and Olaparib Compared to Bevacizumab in Patients with Recurrent Glioblastoma Who Have Not Received Prior VEGF Therapy
| Sponsor: |
National Cancer Institute |
| Enrolling: |
Male and Female Patients |
| IRB Number: |
AAAR9182 |
| U.S. Govt. ID: |
NCT02974621 |
| Contact: |
Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu |
The purpose of this study is to investigate a novel treatment regimen for patients with recurrent Glioblastomas (GBM). In this phase 2 trial, the potentially synergistic action of PARP inhibition and anti-angiogenesis on DNA repair and biomarkers of angiogenesis and DNA repair will be evaluated.
This study is closed
Investigator
Mary Welch, MD
| Are you 18 years of age or older? |
Yes |
No |
| Do you have recurrent glioblastoma? |
Yes |
No |
| Is this the first or second time your glioblastoma reoccurred? |
Yes |
No |
| Did your first treatment include radiotherapy and temozolomide? |
Yes |
No |