Additional Study Information: Approximately half of the individuals with Post-traumatic Stress Disorder (PTSD) present with major depressive disorder (MDD). Compared to PTSD alone, patients with comorbid PTSD-MDD demonstrate greater distress and poorer treatment outcome. The goal of this pilot study is to collect preliminary data on the feasibility, safety, and initial efficacy of an integrated therapeutic approach of a combination treatment with PE and Pramipexole, a dopamine agonist, in treating patients suffering with PTSD and Depression. This study includes pre- and post- treatment research MRI Scans.