Additional Study Information: Why do some individuals continue to experience chronic symptoms of Lyme Disease, such as pain, long after receiving treatment? Through the use of brain imaging (functional MRI) and specific biomarker testing, we hope to gain a better understanding as to why patients develop this persistent, debilitating pain. Based on prior research, we explore whether Lyme disease may change the pattern of an brain activation, making the person more sensitive to pain than a healthy person. If we identify the hyper-activated brain networks in patients with chronic Lyme symptoms, then that information can inform the design of better diagnostic tests as well as new treatment methods that target symptom reduction. We are inviting patients who continue experiencing chronic pain after being treated for Lyme Disease to participate in our study. Study participation will involve a) evaluation: interview and blood test (about 1.5-2 hours; the interview and blood tests can be done remotely or in-person at our institute) and b) a visit to CUIMC for brain imaging, neurocognitive and other tests of sensory sensitivity (total visit time about 5-6 hours, including a break for lunch). If you are interested in participating, please also email us at lymecenter@cumc.columbia.edu with the email subject "fMRI study" and indicate your age and gender in the email.