Additional Study Information: We are inviting healthy volunteers to participate in our brain imaging study. This study aims to investigate persistent pain in Lyme disease. By using brain imaging (functional MRI), we hope to gain a better understanding of why patients have ongoing problems with persistent pain, fatigue, and sensory sensitivity even after antibiotic treatment. We investigate whether Lyme disease changes the pattern of an individual's brain activation, making him or her more sensitive to pain than a healthy person. To test this hypothesis, we will compare patients with chronic Lyme Disease symptoms and healthy individuals on brain imaging, blood tests and other cognitive and sensory tests. The knowledge gained in this study may inform the design of new diagnostic testing and treatments in the future. Study participation will involve a) evaluation: interview and blood test (about 1.5-2 hours; the interview and blood tests can be done remotely or in-person at our institute) and b) a visit to CUIMC for brain imaging and other tests (about 5-6 hours). If you are interested in participating, please also email us at lymecenter@cumc.columbia.edu with the email subject "fMRI study" and indicate your age and gender in the email.