A phase I study of the selective inhibitor of nuclear export (SINE) selinexor in combination with the proteasome inhibitor ixazomib for the treatment of advanced sarcoma
Selinexor in Combination With Ixazomib for the Treatment of Advanced Sarcoma
Sponsor: Matthew Ingham, MD
Enrolling: Male and Female Patients
IRB Number: AAAS0199
U.S. Govt. ID: NCT03880123
Contact: Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu
Additional Study Information: The purpose of this study is to evaluate the safety and effectiveness of a new combination treatment involving two drugs: selinexor and ixazomib, for the treatment of dedifferentiated liposarcoma, malignant peripheral nerve sheath tumor, alveolar soft part sarcoma and Ewing sarcoma. The primary objective of the study is to determine the maximum tolerated dose of the combination of the study drugs. These types of sarcoma are being studied because of earlier research that suggests that combination treatment with selinexor and ixazomib is most likely to be effective for these sarcomas.
This study is closed
Investigator
Matthew Ingham, MD
Do You Qualify?
Are you 14 years of age or older? Yes No
Were you diagnosed with confirmed dedifferentiated liposarcoma, malignant peripheral nerve sheath tumor, alveolar soft part sarc Yes No
Has your sarcoma spread to multiple parts of your body or is it in a location where surgery is not possible? Yes No
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For more information, please contact:
Research Nurse Navigator
cancerclinicaltrials@cumc.columbia.edu
212-342-5162