A Phase II Study of the PARP Inhibitor Olaparib in Combination with the DNA Damaging Agent Temozolomide for the Treatment of Advanced Uterine Leiomyosarcoma
Sponsor: |
NIH |
Enrolling: |
Female Patients Only |
IRB Number: |
AAAS4040 |
U.S. Govt. ID: |
NCT03880019 |
Contact: |
Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu |
The purpose of this study is to test the good and bad effects of olaparib in combination with temozolomide for the treatment of advanced uterine leiomyosarcoma (LMS). Olaparib and temozolomide could shrink your cancer, but could also cause side effects, which are described in the risks section below. The study doctors hope to learn if the study drug will be a safe and effective treatment for people with this type of cancer.
This study is closed
Investigator
Shaheer Khan, DO
Are you 18 years of age or older? |
Yes |
No |
Do you have advanced uterine leiomyosarcoma (LMS)? |
Yes |
No |
Have you had prior progression on, or intolerance to, at least one line of systemic therapy? |
Yes |
No |