Additional Study Information: This is a prospective, randomized, multi-center, controlled study for subjects with end stage liver disease who require a liver transplant, comparing whole liver preservation via hypothermic machine perfusion (HMP) using the LLT System with Vasosol with livers preserved via static cold storage (which is standard of care). During Hypothermic Machine Perfusion, a cold solution is continuously pumped through the liver after the liver is removed from the donor. This is different from the recognized standard of care procedure of cold storage of the liver, which has no solution pumped through the liver. This study will take place at approximately 7 different sites, including here at Columbia University Irving Medical Center. A total of about 140 subjects will be enrolled. Subject care before the transplant and the majority of care after the transplant will be the same whether or not a subject chooses to participate in the study.