Phase 1/2 Study to Evaluate the Safety and Pharmacokinetics of Palbociclib (Ibrance) in Combination with Irinotecan and Temozolomide and in Combination with Topotecan and Cyclophosphamide in Pediatric Patients with Recurrent or Refractory Solid Tumors
Sponsor: |
Pfizer |
Enrolling: |
Male and Female Patients |
IRB Number: |
AAAS2961 |
U.S. Govt. ID: |
NCT03709680 |
Contact: |
Nobuko Hijiya, MD: 212-305-9770 / nh2636@cumc.columbia.edu |
The purpose of this study is to find the best dose of Palbociclib that can be given safely with chemotherapy in children with solid tumor which has come back or has not responded to the standard therapy. Palbociclib works by targeting proteins that are necessary for cell growth. Palbociclib will be given by mouth on Days 1-14 of a 21-day cycle. It will be given in combination with chemotherapy drugs Irinotecan and Temozolomide.
Investigator
Nobuko Hijiya, MD
Does your child have a recurrent or refractory solid tumor? |
Yes |
No |
Is your child between 2 and 21 years old? |
Yes |
No |