Additional Study Information: This study is designed to look at the safety and performance of The Intrepid TMVR System using transfemoral transseptal access (TF). TF is a procedure that requires access to the femoral vein by an incision in the lower limb between the knee and the hip. The study population is for patients with severe, symptomatic mitral regurgitation (MR), a condition where the blood draws back into the mitral valve causing the heart to pump harder. The population of patients are also those who are not eligible for conventional mitral valve surgery. For participants in this study population, the doctors have deemed the risk of experiencing major complications while undergoing open heart surgery very high due to the current medical conditions or anatomical reasons (relating to how and where the heart, mitral valve, and blood vessels are placed within your body). The study may not provide any direct medical benefits. However, since this population suffers from mitral regurgitation that requires treatment, there may be benefit from the procedure for treatment of mitral regurgitation. Participation in this study is expected to last approximately 5 years from the day participant is implanted. However, participants may be asked to continue follow up for ten years.