Additional Study Information: This study is to test if a combination drug/device therapy using TEMSIROLIMUS (Temsirolimus Injection), with or without the generic steroid DEXAMETHASONE (Dexamethasone Sodium Phosphate Injection), can be delivered safely into the tissue around the blood vessel wall at the time of an angioplasty ( which is a a procedure to open blocked arteries and restore blood flow) and whether that delivery helps to prevent re-narrowing of the blood vessel. If you are 18 and have a narrowing or blockage of the blood vessels (arteries) in your leg which your physician has determined needs to be treated with either an angioplasty procedure to improve the blood flow in your leg, you may be eligible for this study if you. You will need to have exams, tests or procedures to find out if you indeed are eligible for the study.Participation in the study will add about 2.5 hours over a 2 year period to your standard of care. There will be scheduled follow-ups and phone interview calls.