A Multicenter, Open-Label, Parallel, Phase 1b/2a Study of PLX2853 in Combination with Abiraterone Acetate and Prednisone and Phase 1b/2a Study of PLX2853 in Combination with Olaparib in Subjects with Metastatic Castration-Resistant Prostate Cancer (mCRPC)
PLX2853 with Abiraterone Acetate, Prednisone, and Olaparib in Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Sponsor: Plexxikon Inc
Enrolling: Male Patients Only
IRB Number: AAAT5555
U.S. Govt. ID: NCT04556617
Contact: Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu
Additional Study Information: In Phase 1b, the purpose is to learn how well patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC) tolerate the treatment when PLX2853 is added to ongoing treatment with abiraterone acetate and prednisone. We are looking for the highest dose of PLX2853 that can be given safely to patients with your type of disease who are already on abiraterone acetate. We will also look at how your body absorbs and breaks down PLX2853 and abiraterone and how effective the combination of PLX2853 and abiraterone acetate is in treating your disease. PLX2853 works by targeting and slowing down certain activities within cells that promote tumor growth. By inhibiting these activities, PLX2853 may help to stabilize or reduce the growth of tumor cells. PLX2853 has shown anti-cancer activity in laboratory studies; however, it is not yet known whether it will work in humans, or if taking PLX2853 and abiraterone acetate together is better than taking abiraterone acetate alone. In the other Phase 2a part of the study we are trying to determine how effective PLX2853 in combination with abiraterone acetate or PLX2853 in combination with olaparib is at treating subjects with mCRPC. We will also look at how PLX2853 and abiraterone or olaparib are broken down and absorbed in the body.
This study is closed
Mark Stein, MD
Do You Qualify?
Are you 18 years or older? Yes No
Have you been diagnosed with prostate cancer? Yes No
You may be eligible for this study

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