Additional Study Information: The purpose of the study is to test an experimental HIV vaccine. The study vaccine is made from two parts: a man-made piece of protein that looks like a protein found on the outside of HIV and an adjuvant. An adjuvant is a substance that helps the immune system respond better. The study will see if the protein and two different amounts of the same adjuvant are safe and if people can get them without being too uncomfortable. The study will also test how peoples immune systems respond to the vaccine made with two different amounts of the same adjuvant. This is the first study to give this vaccine to people. Clinic visits will involve physical exams, collection of blood and urine for routine laboratory tests (including pregnancy tests if you can get pregnant), HIV testing at some visits, and collection of blood samples to look at your immune responses to the vaccine. Some visits will involve questionnaires, some of which ask very personal questions. You will get vaccine injections at three visits. About 105 people will take part in this study at multiple sites, and you will be paid up to $1025 for completing the entire study.