Additional Study Information: The primary objective is to demonstrate that physiologically-guided stenting using the Philips SyncVision iFR co-registration is superior with respect to clinical outcomes compared to PCI guided by angiography alone. Secondary objectives include: To evaluate the cost-effectiveness of physiology guidance with SyncVision compared to a standard of care PCI strategy; To establish the relationship between physiological guidance and improvement in associated angina and quality of life scores; To examine the outcomes in patients in whom an optimized post-PCI iFR can versus cannot be achieved.