Phase II, Neoadjuvant study of parasympathetic stimulation with bethanechol in combination with gemcitabine and nab-paclitaxel in borderline resectable pancreatic adenocarcinoma
Study of Bethanechol in Combination with Chemotherapy for Patients with Pancreatic Cancer
Sponsor: Department of Defense
Enrolling: Male and Female Patients
IRB Number: AAAT5285
U.S. Govt. ID: NCT05241249
Contact: Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu
Additional Study Information: The purpose of this study is to determine whether the drug, bethanechol, could potentially be used in combination with chemotherapy regimen gemcitabine and nab-paclitaxel and surgery to decrease the chance of the cancer coming back after it is removed. Animal models have shown that treatment with bethanechol can inhibit cancer growth and spread. The chemotherapy regimen nab-paclitaxel for use in combination with gemcitabine to treat patients with metastatic pancreatic cancer is FDA-approved. Although bethanechol is FDA-approved, in this study its use is experimental. The aim of the study is to show that the medication is easy to tolerate and that it shows signs of slowing cancer cell growth.
Investigator
Susan Bates, MD
Do You Qualify?
Are you at least 18 years old? Yes No
Have you been diagnosed with pancreatic cancer? Yes No
Do you have a predicted life expectancy of greater than 3 months? Yes No
Have you received chemotherapy or radiotherapy for current diagnosis of pancreatic cancer? Yes No
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For more information, please contact:
Research Nurse Navigator
cancerclinicaltrials@cumc.columbia.edu
212-342-5162