Phase II, Neoadjuvant study of parasympathetic stimulation with bethanechol in combination with gemcitabine and nab-paclitaxel in borderline resectable pancreatic adenocarcinoma
Sponsor: |
Department of Defense |
Enrolling: |
Male and Female Patients |
IRB Number: |
AAAT5285 |
U.S. Govt. ID: |
NCT05241249 |
Contact: |
Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu |
The purpose of this study is to determine whether the drug, bethanechol, could potentially be used in combination with chemotherapy regimen gemcitabine and nab-paclitaxel and surgery to decrease the chance of the cancer coming back after it is removed. Animal models have shown that treatment with bethanechol can inhibit cancer growth and spread. The chemotherapy regimen nab-paclitaxel for use in combination with gemcitabine to treat patients with metastatic pancreatic cancer is FDA-approved. Although bethanechol is FDA-approved, in this study its use is experimental. The aim of the study is to show that the medication is easy to tolerate and that it shows signs of slowing cancer cell growth.
Investigator
Susan Bates, MD
Are you at least 18 years old? |
Yes |
No |
Have you been diagnosed with pancreatic cancer? |
Yes |
No |
Do you have a predicted life expectancy of greater than 3 months? |
Yes |
No |
Have you received chemotherapy or radiotherapy for current diagnosis of pancreatic cancer? |
Yes |
No |