A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients with Methylated MGMT Promoter Glioblastoma
Study of Chemotherapy Drug, Lomustine, in Addition to Temozolomide in Patients with Glioblastoma (GBM)
Sponsor: NIH
Enrolling: Male and Female Patients
IRB Number: AAAT9222
U.S. Govt. ID: NCT05095376
Contact: Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu
Additional Study Information: The purpose of this study is to compare the usual radiation therapy and usual chemotherapy,temozolomide, to using the usual radiation therapy and usual chemotherapy plus thechemotherapy drug lomustine (Gleostine). Lomustine (Gleostine) is already approved by theFDA for use in brain tumors but it is usually used alone and is not the first-line choice formethylated MGMT tumors. Adding a second chemotherapy drug, lomustine (Gleostine), to usual chemotherapy and radiation therapy could extend your life or shrink or stabilize your cancer. But, it could also cause side effects, which the study team will hope to learn more about. This study will help the study doctors find out if this different approach is better than the usualapproach. To decide if it is better, the study doctors will be looking to see if the study approachincreases the life of patients by 6 months or more compared to the usual approach.
Investigator
Fabio Iwamoto, MD
Do You Qualify?
Are you between the ages of 18-70? Yes No
Have you been diagnosed with glioblastoma? Yes No
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For more information, please contact:
Research Nurse Navigator
cancerclinicaltrials@cumc.columbia.edu
212-342-5162