LuMIERE: A Phase 1/2, Multicenter, Open-label,Non-randomized Study to Investigate Safety and Tolerability,Pharmacokinetics, Dosimetry, and Preliminary Activity of177Lu-FAP-2286 in Patients with an Advanced Solid Tumor
Study of 68Ga-FAP-2286 and 177Lu-FAP-2286 in Patients with Advanced Cancer
Sponsor: Clovis Oncology, Inc.
Enrolling: Male and Female Patients
IRB Number: AAAT7518
U.S. Govt. ID: NCT04939610
Contact: Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu
Additional Study Information: The purpose of this study is to test the safety of the experimental drugs called 68Ga-FAP-2286 and 177Lu-FAP-2286. 68Ga-FAP-2286 is an imaging agent that targets a certain protein which has been found in certain tumors called Fibroblast activation protein (FAP). Imaging using 68Ga-FAP-2286 will determine if participants are eligible to receive the experimental radiotherapy, 177Lu-FAP-2286, which researchers think may kill cancer cells by delivering radiation to cancer cells that have fibroblast activation protein (FAP). Cancers include: bladder cancer, brain and spinal tumors, breast cancer, colon and rectal cancer, esophageal cancer, gynecologic cancers, head and neck/oral cancers, kidney cancer, liver cancer, lung cancer, skin cancers, pancreatic cancer, prostate cancer, sarcomas, stomach cancer, testicular cancer, and thyroid cancer.
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Are you at least 18 years old? Yes No
Have you been diagnosed with advanced cancer? Yes No
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For more information, please contact:
Research Nurse Navigator
cancerclinicaltrials@cumc.columbia.edu
212-342-5162