Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Persistent Symptoms from Lyme disease: a feasibility, tolerability, and safety study
Vagus Nerve Stimulation: A New Treatment Study for Previously Treated Lyme Disease Patients with Persistent Symptoms
Sponsor: Columbia Lyme & Tick-borne Diseases Research Center
Enrolling: Male and Female Patients
Study Length: 4 Weeks
IRB Number: 8316
Contact: Lyme Center: 646-774-7503 / lymecenter@cumc.columbia.edu
Additional Study Information: Are you suffering from persistent symptoms that began after you were diagnosed and treated with antibiotics for Lyme Disease? This new research study aims to test a new form of treatment for people with persistent symptoms despite antibiotic treatment for Lyme disease. This treatment involves stimulating a nerve on the surface of your ear. This is called transcutaneous (through the skin) auricular (ear) vagus nerve stimulation (taVNS). Published studies report that vagus nerve stimulation (VNS) can help to reduce pain, fatigue, depression, and inflammation; some studies suggest it can improve cognition as well. Until very recently, most VNS devices have been invasive, requiring surgery to implant the device. This has limited the accessibility and broad application of VNS. A non-invasive approach to VNS is now possible. Transcutaneous auricular vagus nerve stimulation (taVNS) offers the potential of being an effective and non-toxic approach to reduce the burden of symptoms in patients with posttreatment Lyme (PTLS). The primary goals of this study are to assess safety, feasibility, and tolerability of taVNS, as well as assess its efficacy in reducing symptoms related to previously treated Lyme Disease. This study will take place over the course of 4 weeks and will enroll patients with several telehealth visits and 3 in-person visits to our research center in New York City.
Investigator
Brian Fallon, MD
Do You Qualify?
Are you between the ages of 18 and 65? Yes No
Do you have a clinical diagnosis of Lyme disease? Yes No
Have you been treated with antibiotics for Lyme disease? Yes No
Are you willing to visit our Center in NYC for at least 3 visits? Yes No
Is fatigue one of your symptoms? Yes No
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You may be eligible for this study

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For more information, please contact:
Lyme Center
lymecenter@cumc.columbia.edu
646-774-7503