A Phase 2 Trial to Evaluate the Safety and Efficacy of Combination Therapies in Patients with Advanced Upper Gastrointestinal Tract Malignancies (EDGE-Gastric)
Sponsor: |
Arcus Bioscience, Inc |
Enrolling: |
Male and Female Patients |
IRB Number: |
AAAU1634 |
U.S. Govt. ID: |
NCT05329766 |
Contact: |
Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu |
The purpose of this study is to help Arcus Biosciences, Inc. (the Sponsor) understand whether study drugs domvanalimab (also called AB154) plus zimberelimab (also called AB122) are safe and effective when given together with and without standard-of-care chemotherapy (FOLFOX) to patients with the type of cancer you have. Domvanalimab and zimberelimab are considered as immunotherapy. This type of treatment works by blocking a protein (programmed death-ligand 1, or PD-L1) that can cause tumors to grow. By blocking this protein, the study drugs may cause your cancer to stop growing or shrink. These study drugs are investigational meaning they are not approved by the United States Food and Drug Administration (US FDA), or any other agencies like the US FDA, to treat your cancer.
Investigator
Ryan Moy, MD
Are you at least 18 years old? |
Yes |
No |
Have you been diagnosed with an upper gastrointestinal cancer (UGI)? |
Yes |
No |
Are you comfortable receiving the study drug through a vein? |
Yes |
No |