A Phase 1/2 Open-Label, Multicenter Study to characterize the Safety and Tolerability of CFT8634 in Subjects With Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null Tumors
Study of Drug - CFT8634 in Patients with Synovial Sarcoma or SMARCB1-Null Tumors
Sponsor: C4 Therapeutics, Inc
Enrolling: Male and Female Patients
IRB Number: AAAU1383
U.S. Govt. ID: NCT05355753
Contact: Research Nurse Navigator: 212-342-5162 / cancerclinicaltrials@cumc.columbia.edu
Additional Study Information: The study drug, CFT8634, is an investigational therapy that has been shown in animal studies to help break down the BRD9 protein, an important protein in the body that helps SMARCB-null tumors, such as your own, to grow. CFT8634 is able to do so by using the body's own protein-recycling equipment. (In short, your cells are capable of breaking down proteins into their amino acid building blocks in order to rebuild themselves again.) By breaking down the BRD9 protein, the study drug may be able to help destroy these cancer cells in humans. The purpose of this study is to find out if treatment with the study drug is safe, to find out the acceptable dose of the medication, and if it has any good or bad effects in people with SMARCB1-perturbed cancers. This is the first time the study drug is being tested in humans and it is not yet approved by the United States Food and Drug Administration (FDA).
This study is closed
Shaheer Khan, DO
Do You Qualify?
Are you at least 18 years old? Yes No
Have you been diagnosed with synovial sarcoma or SMARCB1-null tumors? Yes No
Are you willing and able to swallow pills? Yes No
You may be eligible for this study

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