Additional Study Information: Naloxone-induced withdrawal is also common in out-of-hospital settings in which non-medical persons are asked to administer naloxone to save the lives of their peers. Concerns about the adverse effects of naloxone administration may prevent or delay the use of this lifesaving intervention. The goal of the proposed, proof-of-concept study is to test the combined effects of vaporized marijuana Delta-9-tetrahydracannabinol (THC) with naloxone as a proof of concept towards the possible development of a combined overdose reversal agent with improved tolerability.