Additional Study Information: We are recruiting healthy volunteers, aged 18-65, for a research study on the buildup of excessive liver fat ("fatty liver disease") in people with or at risk for type 2 diabetes because their bodies are resistant to the actions of the blood sugar-lowering hormone, insulin. To do this, we seek to induce temporary insulin resistance in 10-12 healthy volunteers using one dose of either a placebo (inactive drug) or a medication called alpelisib (brand name: Piqray), which is a treatment for certain breast cancers. We will then measure the effect of treatment on blood sugar, insulin, and fat levels during fasting and after drinking a sugary beverage. Participants will receive compensation for their participation, including a stipend (salary) of $300 and reimbursement for travel expenses.