Role of Hyperinsulinemia in NAFLD Pathogenesis: Diazoxide Pilot & Feasibility Study (Diabetes)
Lowering Insulin Levels in Fatty Liver Disease
Sponsor: Dr. Joshua Cook
Enrolling: Male and Female Patients
Study Length: 15 Days
Clinic Visits: 5
IRB Number: AAAU2570
U.S. Govt. ID: NCT05729282
Contact: Zachary Sone: 212-305-9336 / zds2120@cumc.columbia.edu
Additional Study Information: We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, aged 18-70, who are overweight or obese with a body mass index of 25-45, and have been diagnosed with, or are at risk for, prediabetes. Participants will take either placebo (non-drug) or a medication called diazoxide, which lowers insulin levels, twice daily for two weeks, each time along with a drink of a particular type of water. We will perform blood tests at several time points during the study to determine the effect of diazoxide versus placebo on blood levels of insulin, glucose (sugar), and certain fats. Participants will attend four (4) outpatient visits plus a screening visit as part of the study and will be compensated up to a total stipend (salary) of $550 and reimbursement for travel expenses. If you are found ineligible to participate in this study, you may be asked to join similar, related studies that we are conducting.
Investigator
Joshua Cook, MD, PhD
Do You Qualify?
Is your body mass index between 25 (overweight) and 45 (obesity)? Yes No
Have you ever been diagnosed with diabetes? Yes No
Will you be able to attend 5 visits (each 1-2 hours) at 8:00 AM, including two on back-to-back days over a period of 2 weeks? Yes No
Are you okay with having your blood drawn? Yes No
Women under 50: do you use birth control (pills/implant/IUD/surgical), even if abstinent? (Men & women over 50: answer Yes) Yes No
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Place Holder




For more information, please contact:
Zachary Sone
zds2120@cumc.columbia.edu
212-305-9336