Role of Hyperinsulinemia in NAFLD Pathogenesis: Diazoxide Pilot & Feasibility Study (Diabetes)
Sponsor: |
Dr. Joshua Cook |
Enrolling: |
Male and Female Patients |
Study Length: |
15 Days |
Clinic Visits: |
5 |
IRB Number: |
AAAU2570 |
U.S. Govt. ID: |
NCT05729282 |
Contact: |
Zachary Sone: 212-305-9336 / zds2120@cumc.columbia.edu |
We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, aged 18-70, who are overweight or obese with a body mass index of 25-45, and have been diagnosed with, or are at risk for, prediabetes. Participants will take either placebo (non-drug) or a medication called diazoxide, which lowers insulin levels, twice daily for two weeks, each time along with a drink of a particular type of water. We will perform blood tests at several time points during the study to determine the effect of diazoxide versus placebo on blood levels of insulin, glucose (sugar), and certain fats. Participants will attend four (4) outpatient visits plus a screening visit as part of the study and will be compensated up to a total stipend (salary) of $700 and reimbursement for travel expenses. If you are found ineligible to participate in this study, you may be asked to join similar, related studies that we are conducting.
Investigator
Joshua Cook, MD, PhD
Is your body mass index between 25 (overweight) and 45 (obesity)? |
Yes |
No |
Have you ever been diagnosed with diabetes? |
Yes |
No |
Will you be able to attend 5 visits (each 1-2 hours) at 8:00 AM, including two on back-to-back days over a period of 2 weeks? |
Yes |
No |
Are you okay with having your blood drawn? |
Yes |
No |
Women under 50: do you use birth control (pills/implant/IUD/surgical), even if abstinent? (Men & women over 50: answer Yes) |
Yes |
No |