Additional Study Information: The goal of this research study is to compare evidence-based tele-therapies for patients with non-metastatic breast cancer and comorbid major depression. Participants will be randomly assigned (like by the flip of a coin) to receive twelve weeks of either interpersonal therapy (IPT) or pharmacotherapy with a serotonin reuptake inhibitor, either venlafaxine XR (Effexor) or escitalopram (Lexapro). All sessions will be held virtually via Zoom. Participants will be assessed by independent evaluators and will complete self-report questionnaires throughout the study. There will be a blood sample collected at the beginning and end of the study to measure C-reactive protein, a marker of inflammation elevated in both breast cancer and depression. Participants will be offered $50 compensation as a token of thanks for completing the final evaluation at Week 12.