A Seamless Phase 2A-Phase 2B Randomized Double-Blind Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients with Early Alzheimer's Disease
BenfoTeam Trial: A new approach in early Alzheimers disease research, including Mild Cognitive Impairment and early dementia
Sponsor: National Institutes of Health
Enrolling: Male and Female Patients
Study Length: 76 Weeks
Clinic Visits: 11
IRB Number: AAAV5457
U.S. Govt. ID: NCT06223360
Contact: Sam Cammack: 212-305-4057 / benfoteam@cumc.columbia.edu
Additional Study Information: The BenfoTeam clinical research trial is based on evidence from decades of research on the role of thiamine in Alzheimer's disease (AD). BenfoTeam scientists have found that thiamine (vitamin B1) does not enter the brains of people with early Alzheimer's disease despite having a sufficient supply of thiamine in their blood. Fortunately, there is also evidence that this problem with thiamine in the brain may be overcome by boosting the amount of thiamine in the blood far above usual levels. Benfotiamine, a lab-made version of thiamine, is the drug being tested in the BenfoTeam trial. BenfoTeam tests if increasing thiamine in the blood slows cognitive decline in people with early Alzheimer's disease, including Mild Cognitive Impairment (MCI) and mild dementia.
Investigator
Jose Luchsinger, MD
Do You Qualify?
Are you noticing issues with your memory? Yes No
Do you have a person in your life who could be your study partner and be available for all study visits? Yes No
Do you speak either English or Spanish? Yes No
Do you have major depression or uncontrolled depression? Yes No
Have you been diagnosed with cancer in the last five years? Yes No
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For more information, please contact:
Sam Cammack
benfoteam@cumc.columbia.edu
212-305-4057
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