Human Models of Selective Insulin Resistance: Diazoxide, Part I
Lowering Insulin to Decrease Liver Fat Production
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases
Enrolling: Male and Female Patients
Study Length: 2 Weeks
Clinic Visits: 5
IRB Number: AAAV7588
Contact: Ishwari Nagnur: 212-305-9336 / imn2113@cumc.columbia.edu
Additional Study Information: We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, ages 18-65, who have obesity with a body mass index of 30-45, and have been diagnosed with, or are at risk for, prediabetes and metabolic dysfunction-associated steatotic liver disease (MASLD, also known as "fatty liver disease"). Participants will take a placebo (inert non-drug) or a medication called diazoxide, which lowers insulin levels, twice daily for two 1-week periods, separated by 4-12 weeks. They will also drink a special form of water twice daily. We will perform blood tests at several time points during the study to determine the effect of diazoxide versus placebo on blood levels of insulin, glucose (sugar), and certain fats. Participants will attend four (4) outpatient visits plus two screening visits as part of the study and will be compensated up to a total stipend (salary) of $1100 and reimbursement for travel expenses. If you are found ineligible to participate in this study, you may be asked to join similar, related studies that we are conducting.
This study is closed
Investigator
Joshua Cook, MD, PhD
Do You Qualify?
Is your body mass index between 30 and 45 kilograms per square meter? Yes No
Have you ever been diagnosed with diabetes? Yes No
Will you be able to attend two screening visits and then, over a period of 4-12 weeks, four (4) visits? Yes No
Are you okay with having your blood drawn and receiving study medications? Yes No
Are you pregnant, breastfeeding, or trying to get pregnant? Yes No
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You may be eligible for this study

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For more information, please contact:
Ishwari Nagnur
imn2113@cumc.columbia.edu
212-305-9336