Human Models of Selective Insulin Resistance: Diazoxide, Part I
| Sponsor: |
National Institute of Diabetes and Digestive and Kidney Diseases |
| Enrolling: |
Male and Female Patients |
| Study Length: |
2 Weeks |
| Clinic Visits: |
5 |
| IRB Number: |
AAAV7588 |
| Contact: |
Ishwari Nagnur: 212-305-9336 / imn2113@cumc.columbia.edu |
We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liver disease") in people at risk for type 2 diabetes. We are seeking adult volunteers, ages 18-65, who have obesity with a body mass index of 30-45, and have been diagnosed with, or are at risk for, prediabetes and metabolic dysfunction-associated steatotic liver disease (MASLD, also known as "fatty liver disease"). Participants will take a placebo (inert non-drug) or a medication called diazoxide, which lowers insulin levels, twice daily for two 1-week periods, separated by 4-12 weeks. They will also drink a special form of water twice daily. We will perform blood tests at several time points during the study to determine the effect of diazoxide versus placebo on blood levels of insulin, glucose (sugar), and certain fats. Participants will attend four (4) outpatient visits plus two screening visits as part of the study and will be compensated up to a total stipend (salary) of $1100 and reimbursement for travel expenses. If you are found ineligible to participate in this study, you may be asked to join similar, related studies that we are conducting.
This study is closed
Investigator
Joshua Cook, MD, PhD
| Is your body mass index between 30 and 45 kilograms per square meter? |
Yes |
No |
| Have you ever been diagnosed with diabetes? |
Yes |
No |
| Will you be able to attend two screening visits and then, over a period of 4-12 weeks, four (4) visits? |
Yes |
No |
| Are you okay with having your blood drawn and receiving study medications? |
Yes |
No |
| Are you pregnant, breastfeeding, or trying to get pregnant? |
Yes |
No |