Additional Study Information: This study is for patients who have been diagnosed with systemic Lupus erythematosus (SLE). SLE is a disease in which the body mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain and other organs. The purpose of this study is to test the effects of an investigational (being tested) study drug, CC 220, in order to find out if CC-220 can or cannot improve the symptoms of SLE. This study will test two different doses of CC-220 compared to placebo. The placebo is a sugar pill that contains no study medication (or CC-220), but looks exactly like the study medication capsule. This study will test how well the body tolerates CC-220 and how well CC-220 treats SLE.