A Phase 1 First-in-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 228 in Subjects with Selected Advanced Solid Tumors
Sponsor: |
Amgen |
Enrolling: |
Male and Female Patients |
IRB Number: |
AAAO9909 |
U.S. Govt. ID: |
NCT02437916 |
Contact: |
Victoria Vulaj: 212-305-0455 / vv2218@columbia.edu |
This study is for patients with the following cancers: advanced non-small cell lung cancer, head and neck cancer, melanoma, colon cancer, or bladder cancer. The purpose of this study is to find out more about the effects of AMG 228 in people and on their cancer. AMG 228 is an experimental drug that is being developed to stimulate the bodys immune system to kill cancer cells. This study is the first totest AMG 228 in people. This study will look at what doses of AMG 228 are safe for people totake and whether it causes any side effects. The first group of patients will receive a lower dose and then, if the drug is well tolerated, additional groups of patients will receive the medicine at a higher dose.
This study is closed
Investigator
Yvonne Saenger, MD
Have you been diagnosed with an advanced solid tumor? |
Yes |
No |
Do you have an active autoimmune disease/ history of autoimmune disease |
Yes |
No |