Dr. Kastrinos is a clinical gastroenterologist with interests related to the genetics, screening, and primary prevention of gastrointestinal tumors, primarily colorectal and pancreatic cancer. She has expertise in the genetic evaluation of patients at risk for hereditary gastrointestinal cancer syndromes and directs a multi-disciplinary specialty clinic at the Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, for genetic risk assessment and cancer prevention in familial gastrointestinal syndromes. She has expertise in clinical cancer genetics, statistical methodology involving the genetic epidemiology of cancer predisposition syndromes, development of prediction models, and analyses of large databases. Her research focus complements her clinical interests and involves optimizing the identification of patients with inherited cancer syndromes and promoting existing and testing novel cancer screening and prevention strategies. She has led large-scale studies, and multiple national and international collaborations in developing tools to improve genetic risk assessment for inherited colorectal and pancreatic cancers and developing guidelines for optimal surveillance strategies for individuals at high risk for these cancers. She serves as site-PI at Columbia University for the (i) Cancer of the Pancreas Screening (CAPS) multicenter consortium (U01); (ii) Circulating Biomarker Consortium for the Early Detection of Pancreatic Cancer (U01); (iii) international prospective clinical trial for the validation of a novel biomarker for the early diagnosis of pancreatic cancer in high-risk individuals with familial pancreatic cancer (Immunovia-PanFAM1).