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Displaying 1 - 6 of 6

Learning and the Brain in Obsessive-Compulsive Disorder (OCD)

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Amy Rapp, PhD
Status: Closed
The goal of the project is to identify differences in learning in obsessive-compulsive disorder (OCD) by measuring the activity of the brain while participants complete computer tasks. Eligible participants will be asked questions about their medical and psychiatric history and perform tasks on a computer while an…
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A Brain Imaging Study of Cannabinoid Medication for Adults with OCD

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Reilly Kayser, MD
Status: Closed
The Center for OCD Research at Columbia University Irving Medical Center is seeking individuals with obsessive-compulsive disorder (OCD) to participate in a research study, at no cost to you. This study is investigating the medicinal effects of nabilone for OCD symptoms. Nabilone is a synthetic form of tetrahydrocannabinol (THC), which is one of the active…
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Control and Reward Circuits in OCD

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
This study is investigating how the brains of people with OCD may change with treatment. The study uses Magnetic Resonance Imaging (MRI) to scan the brain, and the treatment used is a form of Cognitive-Behavioral therapy consisting of Exposure and Ritual Prevention (EX/RP). Participants will…
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Non-Invasive Stimulation for Obsessive Compulsive Disorder (OCD)

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Yagna Pathak, PhD
Status: Closed
The study aims to assess the impact of repetitive transcranial magnetic stimulation (rTMS) on brain imaging and neurophysiological measures in patients with Obsessive-Compulsive Disorder (OCD).
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HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

Condition: Blood Disorders / Amyloidosis
Investigator: Thomas Brannagan, MD
Status: Closed
HELIOS-A is a global Phase 3 randomized, open-label study designed to evaluate the safety and efficacy of ALN-TTRSC02 in adult patients with hATTR amyloidosis experiencing neurologic symptoms brought on by the disease. The study will also evaluate any changes in quality of life experienced by study participants. ALN-TTRSC02 utilizes the mechanism of RNA…
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Effects of Marijuana on Symptoms of OCD

Condition: Psychiatric Disorders / Obsessive Compulsive Disorder (OCD)
Investigator: Helen Simpson, MD, PhD
Status: Closed
The purpose of this pilot research study is to test whether certain components of the marijuana plant, known as "cannabinoids", may help to reduce symptoms in patients with OCD. Specifically, patients enrolled in the study will smoke marijuana containing different concentrations of 2 different cannabinoids, THC and CBD. Both of these agents act on the…
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