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Collection of Blood and Skin Samples from Patients with Hair and Skin Disorders

Condition: Hair and Skin Disorders

Status: Currently Recruiting

The purpose of this study is to examine the causes and pathology of alopecia areata and other hair and skin disorders. Skin biopsies and blood and/or clinical information collected in the study will be used for research aiming at developing new options for the treatment of alopecia areata and other skin and hair disorders.

Genetic Studies of Hidradenitis Suppurativa

Condition: Hair and Skin Disorders

Investigator: Lynn Petukhova, PhD

Status: Closed

Genetic studies help us to understand why some people develop certain diseases while others don't and also provide important clues about how best to treat the disease.

Insulin Action in Psoriasis

Condition: Hair and Skin Disorders

Investigator: Joshua Cook, MD, PhD

Status: Closed

We are conducting a research study on how psoriasis might be caused or worsened by high levels of the blood sugar-lowering hormone insulin. We are seeking people with plaque psoriasis, ages 18-65, who are overweight or obese with a body mass index of 25-35. Participants will have blood drawn and small skin biopsies taken from psoriasis plaques and nearby…

A Study of Rucaparib as Treatment for Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: June Hou, MD

Status: Closed

The experimental drug being investigated in this study is called rucaparib. Rucaparib is being developed by Clovis Oncology, Inc. (the Sponsor), a biopharmaceutical company with headquarters in the United States (US). Rucaparib (trade name: Rubraca) is a medicine that is approved in the European Union (EU) and the US for use in certain types of ovarian…

A study for subjects with Unilateral Menieres disease using corticosteroid (OTO-104)

Condition: Meniere's Disease

Investigator: Anil Lalwani, MD

Status: Closed

Meniere's Disease is an inner ear disorder that causes episodes of vertigo. The purpose of this study is to test the effectiveness and safety of OTO-104 compared to placebo in subjects with Menieres disease. OTO-104 contains an active ingredient, called dexamethasone, which is a commonly used corticosteroid that has been prescribed by doctors for…

Study of SY-1365 in Adult Patients with Advanced Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: June Hou, MD

Status: Closed

SY-1365 is an investigational drug that stops the function of a protein known as CDK7. Previous workhas shown that CDK7 is necessary for some cancers to grow. Therefore, SY-1365 could be used to slow down the growth of cancer. This research study is being done to understand the highest tolerated dose of SY-1365, and to assess the safety of SY-1365 in…

Study of VX15/2508 in Children, Adolescents, or Young Adults with Recurrent or Relapsed Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: Luca Szalontay, MD

Status: Closed

This is a Phase 1/2 multicenter study of VX15/2503 in pediatric patients and young adults with solid tumors which have come back or have not responded to standard therapy. The study treatment is considered experimental because VX15/2503 is not approved by the United States (US) Food and drug Administration (FDA) for treating pediatric patients and young…

Study of TSR-042 (anti-PD-1 Monoclonal Antibody) in Patients with Advanced Solid Tumors

Condition: Cancer / Solid Tumors

Investigator: June Hou, MD

Status: Closed

The study drug (TSR-042) in this study is designed to stop cancer from growing by helping your immune system recognize and fight the cancer. The Study Drug is designed to help your immune system by attaching to a protein called PD-1 and stopping one of the signals that keeps your immune system from recognizing the cancer. This may help your immune system…

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