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Displaying 201 - 258 of 258
Condition: Healthy Volunteers
Investigator: Sharon Wardlaw, MD
Status: Closed
This 2-phase study aims to explore ways to predict who will respond well to the FDA approved weight loss drug lorcaserin and to understand the mechanisms that develop which limit drug efficacy. Subjects will be recruited for a 5-week crossover study (phase 1) with lorcaserin and placebo followed by treatment with lorcaserin for 24 weeks (phase 2). Phase 1…
Condition: Cancer / Breast Cancer
Investigator: Kevin Kalinsky, MD, MS
Status: Closed
The purpose of this study is to determine whether the combination of study drugs Ruxolitinib plusTrastuzumab is safe and effective in stopping breast tumor growth in patients with HER2 positivemetastatic breast tumors who have already received Trastuzumab. Trastuzumab (Herceptin) is an FDA-approved treatment for HER2 positive breast cancer.
Condition: Healthy Volunteers
Investigator: Billy Caceres, PhD, RN
Status: Closed
This goal of this study is to learn more about how stress and coping might be associated with blood pressure in lesbian, gay, and bisexual adults. If you are deemed eligible, first you will be scheduled for a telephone or video conference interview with a member from the study team, which may take up to 1.5 hours. For the interview, you may be asked to…
Condition: Cancer / Breast Cancer
Investigator: Melissa Accordino, MD
Status: Closed
The purpose of this research study is to determine if the experimental drug balixafortide combined with eribulin is well tolerated and more effective for treating breast cancer compared with eribulin given alone. Balixafortide (POL6326) interacts with proteins called CXCR4 receptors which may directly suppress tumor growth through disruption of signaling…
Condition: Cancer / Breast Cancer
Investigator: Kevin Kalinsky, MD, MS
Status: Closed
The purpose of this study is to compare the effects, good and/or bad, of study drug cobimetinib and paclitaxel for patients with metastatic truple-negative breast cancer (mTNBC). In this study, you will receive either a combination of cobimetinib and paclitaxel or placebo (no active medication) and paclitaxel. The study will also evaluate what side effects…
Condition: Healthy Volunteers
Investigator: Paula Castano, MD, MPH
Status: Closed
Columbia University is conducting a contraceptive clinical trial looking at two intrauterine devices, one of which is investigational. Pre-menopausal women ages 16-40 who are generally healthy, sexually active, at risk for pregnancy, and are not at risk for sexually transmitted infections may qualify.
Condition: Cancer / Breast Cancer
Investigator: Katherine Crew, MD
Status: Closed
To assess whether prophylactic beta blocker therapy with carvedilol compared with no intervention reduces the risk of subsequent cardiac dysfunction in patients with metastatic breast cancer receiving trastuzumab-based HER-2 targeted therapy.
Condition: Healthy Volunteers
Investigator: Kevin Ochsner, PhD
Status: Closed
The Social Cognitive and Affective Neuroscience (SCAN) Lab is currently running research studies to investigate social interactions. Our beliefs about those who are close to us are based on our previous interactions with them. This experiment examines exactly how interactions with close others lead to changes in our beliefs about their personality and our…
Study of Safety and Efficacy of Eribulin in Combination with Pembrolizumab in Breast Cancer Patients
Condition: Cancer / Breast Cancer
Investigator: Kevin Kalinsky, MD, MS
Status: Closed
The purpose of this study is to evaluate the effectiveness and safety of eribulin mesylate (eribulin) incombination with pembrolizumab in metastatic (spread of cancer from one part of body to another) triple-negative breast cancer (mTNBC).
Condition: Healthy Volunteers
Investigator: Christine Kim Garcia, MD
Status: Closed
The FAR-ILD study is designed to detect and study the earliest stages of ILD in adults with a family history of ILD. FAR-ILD is a non-interventional study. This means that FAR-ILD is not involved in testing any new interventions or therapies. The purpose of FAR-ILD is to gather data on family members of patients with pulmonary fibrosis over a long period of…
Condition: Cancer / Breast Cancer
Investigator: Kevin Kalinsky, MD, MS
Status: Closed
This study is for women with breast cancer who will be undergoing lumbar puncture to evaluate for the presence of leptomeningeal metastasis, a complication in which the cancer spreads to the membranes (meninges) surrounding the brain and spinal cord. This condition is typically diagnosed by examining the cerebrospinal fluid obtained from the lumbar puncture…
Condition: Healthy Volunteers
Investigator: Julia Wynn
Status: Closed
This study is evaluating genomic screening in Ashkenazi Jewish and Hispanic communities. Genomic screening is done by collecting a blood sample and looking at a person's genes to learn if they are at high risk for certain health problems like cancer or heart disease or are at risk to have a child with a genetic condition. The study is designed to…
Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, MD
Status: Closed
We are looking for healthy, HIV-negative individuals 18 to 50 years old who are interested in our studies that test antibodies for HIV prevention. Antibodies are one of the natural ways that our bodies fight or prevent infection. We are testing an antibody called VRC07-523LS against HIV. We will ask you to complete a brief questionnaire to find out if you…
Condition: Healthy Volunteers
Investigator: Yuval Neria, PhD
Status: Closed
Columbia University Medical Center is presently recruiting healthy individuals to participate in an fMRI research study. For your participation, you will receive up to $270 and an opportunity to advance research in the area of trauma and PTSD. This study involves two visits.
Condition: Healthy Volunteers
Investigator: Elizabeth Shane, MD
Status: Closed
Osteoporotic fractures affect the lives of 1.5 million Americans each year. Imaging tests, such as bone density, are used to predict fracture risk and to help guide therapy for fracture prevention. In this study we are validating a high-resolution, three-dimensional scanner with the overall goal of improving the diagnosis of bone diseases.
Condition: Healthy Volunteers
Investigator: Yael Cycowicz, Ph.D.
Status: Closed
This study investigates changes in brain responses to visual images presented both frequently and infrequently. 60 adults will be recruited for the study which will take place in a laboratory at the New York State Psychiatric Institute. You will see the visual images on a computer screen and will have to respond with a button press to only one image while…
Condition: Cancer / Breast Cancer
Investigator: Meghna Trivedi, MD
Status: Closed
The goal of this study is to determine if ribociclib in combination with letrozole as neoadjuvant endocrine therapy increases the proportion of women with PEPI score of 0 at surgery, compared to patients treated with letrozole alone therefore allowing more patients excellent outcomes without chemotherapy. The PEPI score measures the risk of breast cancer…
Condition: Healthy Volunteers
Investigator: Franklin Schneier, MD
Status: Closed
We are currently enrolling healthy individuals to participate in a research study involving electroencephalography (EEG) and magnetic resonance imaging (MRI). Participants will complete 3 visits over the course of 2 weeks and receive up to $400 for their participation. The visits will involve a psychiatric assessment and medical history, playing computer…
Condition: Cancer / Breast Cancer
Investigator: Dawn Hershman, MD
Status: Closed
The purpose of this study is to see whether treatment with everolimus plus hormone treatment after chemotherapy will increase the time without the subjects cancer returning. The current standard treatment after chemotherapy is hormone treatment alone. Everolimus is a drug currently approved for the treatment of patients with advanced or metastatic kidney…
Condition: Healthy Volunteers
Investigator: Lawrence Kegeles, MD
Status: Closed
PAID RESEARCH VOLUNTEERS NEEDED Healthy volunteers, age 18-35 years, needed for a research study. Study requirements:- 2-3 hours of clinical assessments and neurocognitive testing -1 hour MRI As a participant you will receive: $100 for the MRI; $10/ hour for other testing; participants can make up to $200.00 For further information about the study and your…
Condition: Cancer / Breast Cancer
Investigator: Katherine Crew, MD
Status: Closed
The purpose of this study is to determine the effect of different doses of ZN-c5 on levels of hormone (estrogen) receptors in breast cancer and how large that effect is for each dose level. The amount of reduction in hormone receptors may indicate that the drug is doing what it intends to do and how effective it is. The results will help define what an…
Condition: Healthy Volunteers
Investigator: Billy Caceres, PhD, RN
Status: Closed
The goal of this study is to conduct interviews with lesbian, gay, bisexual, transgender, and queer (LGBTQ) adults ages 40-64 years to explore sources of stress, stress management techniques, and heart disease risk behaviors (such as smoking). We will also identify preferred modalities for a stress management intervention to reduce heart disease risk in…
Condition: Cancer / Breast Cancer
Investigator: Andrew Lassman, MD
Status: Closed
The purpose of this study is to gather information on the safety of TH-302 and its effect on patients with HER2+ breast cancer. This study will also look at how the drug is processed in the body. In addition, this study will collect data from blood, tumor, and imaging studies about this specific cancer such as the level of oxygen that is present. This may…
Condition: Healthy Volunteers
Investigator: Micaela Martinez, PhD
Status: Closed
This study involves wearing a small light sensor on a lanyard and a temperature sensor in a wristband for one week in the summer, fall, winter and spring. The study will span 9 months. Participants will also be asked to fill out a daily questionnaire during those weeks. $30/week compensation or $120 in total for participation.
Condition: Healthy Volunteers
Investigator: Adam Brickman, PhD
Status: Closed
This study is associated with the Alzheimer's Disease Research Center (ADRC) at Columbia University. The study seeks to understand changes in the way the brain's structure and function are related to age, and the risk of developing memory problems, Alzheimer's disease (AD), and dementia. The study will use magnetic resonance imaging (MRI) to…
Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, MD
Status: Closed
Antibodies are one of the natural ways that our bodies fight or prevent infection. Were testing an antibody to find out if its safe, if they don't make people feel uncomfortable, how these study antibodies move throughout the body, and to measure antiviral activity. You cannot get HIV from the study antibody. Firstly, request to be contacted by our…
Condition: Cancer / Breast Cancer
Investigator: Allison Borowski, MD
Status: Closed
We are currently recruiting women to TMIST, a clinical trial that will help us develop strategies that tailor breast cancer screening to the risks of individual women. This is a screening trial. The purpose of this trial is to determine if tomosynthesis (3-D) mammography detects breast cancer at earlier stage than current method of 2-D digital mammography.
Condition: Healthy Volunteers
Investigator: Christine Kim Garcia, MD
Status: Closed
Are you a current or former smoker? Do you want to know more about your lung health? The FAR-ILD study is designed to detect and study the earliest stages of ILD in at-risk adults, including older smokers. FAR-ILD is a non-interventional study. This means that FAR-ILD is not involved in testing any new interventions or therapies. The purpose of FAR-ILD is…
Condition: Cancer / Breast Cancer
Investigator: Bret Taback, MD
Status: Closed
Some people who are treated for breast cancer develop swelling in their arms as a result of their treatment. This swelling is called lymphedema and it can be chronic. The purpose of this study is to see if early detection of arm swelling using a small painless device (called bioelectrical impedance), immediately followed by compression treatment, prevents…
Condition: Healthy Volunteers
Investigator: Joyce Yu, MD
Status: Closed
The population includes males and females of all ages with one or more food allergy or those who are at risk of mortality from food-induced anaphylaxis. The FARE Patient Registry is a multicenter, prospective, longitudinal, observational cohort study of patients with food allergy. The participant and the treating physician agree that he/she will complete…
Condition: Healthy Volunteers
Investigator: Marla Hamberger, PhD
Status: Closed
Some medical conditions in children involve difficulty with speech and language. Therefore, accurate measurement of these difficulties is important for both diagnosis and treatment. Unfortunately, the test that is currently used to assess object naming-- one of the most common language problems found in these conditions is the same test that is used for…
Condition: Healthy Volunteers
Investigator: Carmela Alcantara, PhD
Status: Closed
The Latino Sleep and Health Study (LASH) is a community study of Latino adults that is focused on understanding the relationship between sleep, stress, self-control, and health. Participation in LASH is fairly simple. If you are found eligible after taking the screener, you will be asked to complete an in-person survey. You can earn $20 for after completing…
Condition: Cancer / Breast Cancer
Investigator: Dawn Hershman, MD
Status: Closed
This randomized clinical trial studies prophylactic colony stimulating factor management in patients with breast, colorectal or non-small cell lung cancer receiving chemotherapy and with risk of developing febrile neutropenia. Patients receiving chemotherapy may develop febrile neutropenia. Febrile neutropenia is a condition that involves fever and a low…
Condition: Healthy Volunteers
Investigator: Erika Berman-Rosenzweig, MD
Status: Closed
This research study is being conducted to study pulmonary hypertension and right heart dysfunction based on clinical, imaging, physiological and pathological characteristics. We hope to develop a new classification system and new methods to diagnose and treat pulmonary hypertension. Diagnostic testing includes (listed subsequently): full medical work-up,…
Condition: Healthy Volunteers
Investigator: Yuval Neria, PhD
Status: Closed
Emerging research has demonstrated a relationship between visual attention patterns and anxiety disorders, including PTSD. This study is designed to examine these visual attention patterns using eye-tracking A simple device that monitors eye-movements. The study included two sessions conducted approximately 1 week apart, each no longer than 1 hour. In both…
Condition: Cancer / Breast Cancer
Investigator: Kevin Kalinsky, MD, MS
Status: Closed
Tomography (DOT), can help predict how well patients respond to a pre-surgical therapy. This imaging technique uses light to create 3D maps of the blood, fat, and water content of the breast. Based on these measurements taken over 2 time points during therapy (before and after), we will try to determine if this new imaging technique can use early…
Condition: Healthy Volunteers
Investigator: Thomas Nickolas, MD, MS
Status: Closed
The BoneGN study will help us learn how bones and muscles are responding to Glomerular Diseases. These conditions may gradually weaken bones and increase the risk of having a fracture (broken bone). In the future, the results can contribute in developing strategies to improve the bone health. We are looking for healthy children and adults between 5 and 55…
Condition: Healthy Volunteers
Investigator: Sharon Mannheimer, MD
Status: Closed
This is a COVID transmission study happening across the US to help us learn whether the COVID-19 vaccine stops the spread of the SARS-CoV-2 virus (COVID): both initial infection and transmission to others. The answer to this question can have an important impact on all of our lives. Currently we are enrolling unvaccinated people. You will not be required to…
Condition: Cancer / Breast Cancer
Investigator: Bret Taback, MD
Status: Closed
The purpose of this study is to capture and evaluate clinical data about the long-term safety and effectiveness of Novilasee - a FDA-cleared minimally invasive treatment for benign breast tumors in hopes that tracking and analyzing the safety and effectiveness of Novilase in a real world application will benefit future patients and the breast cancer…
Condition: Healthy Volunteers
Investigator: Helen Simpson, MD, PhD
Status: Closed
The purpose of this research study is to learn whether exercise affects learning and memory in people with anxiety. This is not a treatment study. The exercise program in this study runs for 6 weeks total. Each week, you are required to exercise 4 times for 12-15 minutes on the stepper machine that will be provided for you. You will be asked to visit our…
Condition: Healthy Volunteers
Investigator: Karen Bell, MD
Status: Closed
The purpose of this study is to test whether an investigational drug called solanezumab can slow the progression of memory problems associated with brain amyloid. The study will also test 1) whether the anti-amyloid treatment can slow evidence of AD-related brain injury on imaging tests to look at brain structure and function and 2) the effect of…
Condition: Healthy Volunteers
Investigator: Magdalena Sobieszczyk, MD
Status: Closed
Almost 40,000 people get HIV in the U.S. each year and almost all occur via sexual contact, especially male-to-male contact. The number of new infections has decreased slightly each year, however, we need other HIV prevention tools, such as developing a greatly, effective HIV vaccine, to better reduce HIV infections. SCREENING AND EDUCATION: 1. Consent will…
Condition: Cancer / Breast Cancer
Investigator: Kevin Kalinsky, MD, MS
Status: Closed
The purpose of this trial is to determine whether the study drug, CX-839, reduces tumor size in patients with metastatic triple negative breast cancer when it is used in combination with the standard breast cancer treatment. CX-839 blocks the activity of a certain molecule that is overproduced by some cancer cells.
Condition: Healthy Volunteers
Investigator: Melanie Gold, MD
Status: Closed
Auriculotherapy is a type of Eastern medicine that has been used for thousands of years involving the ear. The ear has nerve connections to the whole body, and therefore using non-invasive techniques can be used to treat a wide variety of problems. This study is looking to see if auriculotherapy might be used to treat abdominal pain and find areas on the…
Condition: Cancer / Breast Cancer
Investigator: Kevin Kalinsky, MD, MS
Status: Closed
The purpose of this research study is to determine if using a piece of the patient's residual tumor to develop a model of her cancer in mice that lack an immune system (also called an immune-deficient mouse) could help in determining which additional drugs or compounds to which an individual breast tumor is sensitive. The tumor implanted in the mouse…
Condition: Cancer / Breast Cancer
Investigator: Sheldon Feldman
Status: Closed
The main purpose of this study is to determine the safety and tolerability of Faslodex given directly into thebreast ducts of women with invasive breast cancer or Ductal Carcinoma In Situ (DCIS). This study is for women who have been diagnosed with invasive breast cancer or DCIS. DCIS is the presence of abnormal cells inside a milk duct in the breast, and…
Condition: Healthy Volunteers
Investigator: Martha Welch, MD
Status: Closed
The purpose of this current study is to investigate the efficacy of a group model of Family NurtureIntervention in ameliorating behavioral problems in preschool-aged children. The behavioral, neurobiological and clinical insights gained from this project may eventually lead to better treatment of emotional, behavioral and developmental disorders. The…
Condition: Healthy Volunteers
Investigator: Loren Gianini, PhD
Status: Closed
The goal of this study is to better understand why some people have managed to lose weight and keep it off while others have not. We are recruiting people who have lost weight and kept it off as well as healthy non-dieters with overweight or obesity who are not trying to lose weight. Study participation involves computer tasks, brain imaging, and eating a…
Condition: Cancer / Breast Cancer
Investigator: Meghna Trivedi, MD
Status: Closed
The purpose of this study is to identify the doses of spartalizumab (PDR001) with LAG525 in combination with either NIR178, capmatinib (INC280), MCS110 or canakinumab (ACZ885) that can be given safely. The study will also test how well spartalizumab (PDR001) with LAG525 in combination with either NIR178, capmatinib (INC280), MCS110 or canakinumab (ACZ885)…
Condition: Healthy Volunteers
Investigator: Marla Hamberger, PhD
Status: Closed
The purpose of this project is to develop a set of word finding or naming tests for adults, ages 66 and above. The main task involves naming pictures of common objects (e.g. broom), or naming items when given a description (e.g. "what children ride to school in"). There are some other tasks as well such as single word reading, number repetition,…
Condition: Cancer / Breast Cancer
Investigator: Bret Taback, MD
Status: Closed
This is a study for patients diagnosed with either breast cancer that is HER-2 positive, or breast cancer that is negative for estrogen, progesterone and HER-2 (triple-negative disease), and whose tumor can be removed by breast-conserving surgery. The purpose of this study is to test whether patients undergoing a breast MRI (magnetic resonance imaging)…
Condition: Healthy Volunteers
Investigator: Nim Tottenham, PhD
Status: Closed
Parents! Join our research study! For families with 2-4 years olds, Complete from the comfort of your own home! Involves: Complete questionnaires; Collect a stool sample from your child; Provided with an easy to use kit and video instructions; Earn $25 for participating.
Condition: Healthy Volunteers
Investigator: Keith Diaz, PhD
Status: Closed
The phrase sitting is the new smoking has been coined due to an increase of excessive sitting in middle- and older-aged adults. However, there are currently no specific guidelines for the best way to break up long periods of sitting. This study will look at the effect of breaking up sitting periods with movement breaks on blood sugar levels. We are looking…
Condition: Cancer / Breast Cancer
Investigator: Dawn Hershman, MD
Status: Closed
This study examines diffuse optical tomography (DOT) as a way to monitor the progress of the breast cancer therapy. Specifically, it looks at DOTs ability to detect non-responders early in treatment and then adjust the therapy to improve response and overall survival. DOT is favorable to more conventional forms of cancer monitoring, such as physical exams,…
Condition: Healthy Volunteers
Investigator: Yaakov Stern, PhD
Status: Closed
Train the Brain Study: The purpose of this study is to investigate the effect of a web-based (remote, at home) computerized cognitive training protocol on cognitive performance in healthy older adults. Thetraining will involve a daily life situation in a multi-task context. If you are eligible, you will be asked tocomplete 13 web-based sessions, twice a…
Condition: Cancer / Breast Cancer
Investigator: Kevin Kalinsky, MD, MS
Status: Closed
This study involves research; it is the first time that MLN0128 will be studied in patients who are also receiving antihormonal medication. The main purposes of the study are to determine: The risks and discomforts of MLN0128 when given with antihormonal medication. Whether giving MLN0128 in combination with antihormonal medication affects the growthof your…
Condition: Healthy Volunteers
Investigator: Micaela Martinez, PhD
Status: Closed
How does the light we experience in day-to-day life affect our body clock? Interested in joining a new project to help scientists at Columbia University understand how light pollution and light-at-night affects our body clock? You or your child may be eligible to participate. The study involves wearing a small light sensor on a lanyard and a temperature…
Condition: Healthy Volunteers
Investigator: Cassia Wells, MD
Status: Closed
Antibodies are one of the natural ways that our bodies fight or prevent infection. We're testing an antibody to find out if it's safe, if they don't make people feel uncomfortable, how these study antibodies move throughout the body, and to measure antiviral activity. You cannot get HIV from the study antibody. First, request to be contacted…
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