Additional Study Information: The purpose of this study is to understand the life course of PIRD patients and their family members that have the same gene change but do not have the same symptoms. PIRD is mostly due to inherited changes in the genes that normally have immune cells fight infections and regulate the immune system. There are many types of problems that patients with PIRD can develop and some can be life-threatening. We do not know the best way to prevent or treat problems with immune system regulation in PIRD patients. We do not know how having PIRD impacts the quality of life of patients and their families. Also, we do not know the health impact on family members with the same gene change. This study aims to learn more about these questions.