Additional Study Information: The purpose of this research is to learn how to help parent youth pairs work together to help youth with sickle cell disease take hydroxyurea every day as a daily habit. This study is for children and teens ages 10-18 with Sickle Cell Anemia taking hydroxyurea, and their parents (or guardians). Many children and teens do not use hydroxyurea every day. Daily use of hydroxyurea can help it work better to improve health. Taking it every day would be a healthy habit. This study, will evaluate whether those methods are useful for learning to take hydroxyurea every day.