We are recruiting adults with bipolar disorder, and adults with no psychiatric disorder, ages 18-60 years. As a participant in our study, you will be asked to attend one remote or in-person visit and one to two in-person visits. The following procedures will occur: Visit 1 (1 - 2.5 hrs): Clinical interview for overall psychiatric history as well as current…
We will evaluate the D-cycloserine (DCS) and lurasidone with MRI measurement of brain responses to DCS. DCS is a drug that works on the same brain receptor as ketamine. DCS is not approved by the FDA for bipolar depression. Study participants will receive a dose of lurasidone or placebo in one MRI and a dose of DCS in another, followed by an optional follow…
Kidney disease patients have a variety of severe bone disorders that result in rapid bone loss and fractures. We are doing this research study to determine relationships between bone quality determined from bone imaging and bone biopsy and by non-invasive measures from blood and skin. We are…