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Collection of Blood and Skin Samples from Patients with Hair and Skin Disorders

Condition: Hair and Skin Disorders

Status: Currently Recruiting

The purpose of this study is to examine the causes and pathology of alopecia areata and other hair and skin disorders. Skin biopsies and blood and/or clinical information collected in the study will be used for research aiming at developing new options for the treatment of alopecia areata and other skin and hair disorders.

Genetic Studies of Hidradenitis Suppurativa

Condition: Hair and Skin Disorders

Investigator: Lynn Petukhova, PhD

Status: Closed

Genetic studies help us to understand why some people develop certain diseases while others don't and also provide important clues about how best to treat the disease.

Insulin Action in Psoriasis

Condition: Hair and Skin Disorders

Investigator: Joshua Cook, MD, PhD

Status: Closed

We are conducting a research study on how psoriasis might be caused or worsened by high levels of the blood sugar-lowering hormone insulin. We are seeking people with plaque psoriasis, ages 18-65, who are overweight or obese with a body mass index of 25-35. Participants will have blood drawn and small skin biopsies taken from psoriasis plaques and nearby…

Solutions for Celiac Study

Condition: Cancer / Gastrointestinal

Investigator: Peter Green, MD

Status: Closed

This research study is sponsored by ImmunogenX and The National Institutes of Health (NIH, Bethesda, MD). The objective of this study is to determine if the investigational product (latiglutenase) will help decrease symptoms in subjects with celiac disease while maintaining a gluten-free diet while undergoing periodic gluten exposure. In addition, this…

Study of Standard Chemotherapy Alone or Combined with Atezolizumab for Patients with Stage III Colon Cancer

Condition: Cancer / Gastrointestinal

Investigator: Yoanna Pumpalova, MD

Status: Closed

This study evaluates whether the addition of immune therapy to usual FOLFOX chemotherapy in patients with deficient DNA mismatch repair stage III colon cancer can improve your outcome compared to FOLFOX alone. The immune therapy drug, atezolizumab, may allow your body's immune system to more effectively kill cancer cells in your body. One of the…

TARGET-NASH: Longitudinal Observational Study of Patients with Nonalcoholic Fatty Liver or Nonalcoholic Steatohepatitis

Condition: Liver Disease / NASH

Investigator: Elizabeth Verna, MD

Status: Closed

This is a 5-year, longitudinal, observational study of patients with NAFL or NASH designed to specifically address important clinical questions that remain incompletely answered from registration trials. The main purpose of this research study is to collect and study information on patients with NAFLD/NASH.The goal of this study is to observe any treatment…

Study of Emricasan in subjects with Non-Alcoholic Steatohepatitis (NASH) Cirrhosis

Condition: Liver Disease / NASH

Investigator: Elizabeth Verna, MD

Status: Closed

Patients who have been diagnosed with decompensated nonalcoholic steatohepatitis (NASH) cirrhosis may be eligible to participate in this clinical trial. NASH is liver inflammation and damage caused by a buildup of fat in the liver. The main purpose of the study is to test the safety and efficacy of a drug called Emricasan (IDN-6556) in reducing the risk…

Study of Obeticholic Acid in Subjects with Compensated Cirrhosis due to Nonalcoholic Steatohepatitis (NASH)

Condition: Liver Disease / NASH

Investigator: Julia Wattacheril, MD, MPH

Status: Closed

The Sponsor is conducting this study to find out how safe and effective the investigational drug (alsocalled a study drug) obeticholic acid (also known as OCA) may be in improving compensated cirrhosis caused by NASH. Currently, there are no therapies approved for the treatment of NASH. OCA (the brand name is Ocaliva) has been approved in several…

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