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Collection of Blood and Skin Samples from Patients with Hair and Skin Disorders

Condition: Hair and Skin Disorders

Status: Currently Recruiting

The purpose of this study is to examine the causes and pathology of alopecia areata and other hair and skin disorders. Skin biopsies and blood and/or clinical information collected in the study will be used for research aiming at developing new options for the treatment of alopecia areata and other skin and hair disorders.

Genetic Studies of Hidradenitis Suppurativa

Condition: Hair and Skin Disorders

Investigator: Lynn Petukhova, PhD

Status: Closed

Genetic studies help us to understand why some people develop certain diseases while others don't and also provide important clues about how best to treat the disease.

Insulin Action in Psoriasis

Condition: Hair and Skin Disorders

Investigator: Joshua Cook, MD, PhD

Status: Closed

We are conducting a research study on how psoriasis might be caused or worsened by high levels of the blood sugar-lowering hormone insulin. We are seeking people with plaque psoriasis, ages 18-65, who are overweight or obese with a body mass index of 25-35. Participants will have blood drawn and small skin biopsies taken from psoriasis plaques and nearby…

Study of Lutathera in Patients with Glioblastoma (GB)

Condition: Cancer / Brain Cancer

Investigator: Mikhail Doubrovin, MD

Status: Closed

The purpose of the study is to evaluate the safety of Lutathera alone in patients with recurrent glioblastoma and the combination of Lutathera with radiotherapy with temozolomide (TMZ) in patients with newly diagnosed glioblastoma (GB) and to establish the appropriate dose of this combination. Lutathera is a radioligand therapy, which is a targeted…

Study of Focused Ultrasound (FUS) with DEFINITY Microbubbles in Children and Young Adults with Progressive Diffuse Midline Glioma (DMG)

Condition: Cancer / Brain Cancer

Investigator: Stergios Zacharoulis, MD

Status: Closed

Children and young adults with diffuse midline glioma will be treated with Focused Ultrasound (FUS) with DEFINITY microbubbles and neuro-navigator-controlled sonication. The overall goal of this study is to see if the study treatment plan will improve the outcome of participants with diffuse midline glioma, for which no known cure exists, and determine…

Study of ATX-101 in Patients with Dedifferentiated Liposarcoma (LPS) and Leiomyosarcoma (LMS)

Condition: Cancer / Sarcoma

Investigator: Benjamin Izar, MD

Status: Closed

The purpose of this study is to evaluate the effectiveness of a new investigational drug, ATX-101, for the treatment of dedifferentiated liposarcoma and leiomyosarcoma. ATX-101 is an intravenous (IV) drug which blocks the interaction of a protein called PCNA with a number of stress response proteins. These interactions are thought to be important for cancer…

Study of MTX110 in Combination with Gadolinium in Children & Young Adults with Newly Diagnosed Brain Cancer (Diffuse Midline Gliomas)

Condition: Cancer / Brain Cancer

Investigator: James Hinkley Garvin Jr, MD

Status: Closed

The purpose of this study is to find the best dose of a drug called MTX110 and a contrast agent called gadolinium that can be given safely in children with newly diagnosed diffuse midline gliomas, which is a kind of brain tumor. All patients enrolled in the study will receive infusion of MTX110 and Gadolinium delivered with a pump directly into the tumor…

Study to Evaluate AL102 in Patients with Progressing Desmoid Tumors - DUPLICATE

Condition: Cancer / Sarcoma

Investigator: Gary Schwartz, MD

Status: Closed

You are being asked to participate in this study because you have been diagnosed with a progressive desmoid tumor. The purpose of this study is to see if the study drug, called AL102 (referred to from now on as the study drug), is safe and effective in people with progressive desmoid tumors. The study will also look at how your body responds to the study…

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