This study is testing whether giving an investigational drug called C1 esterase inhibitor (C1INH) directly into the donor kidney before transplant can improve kidney function one year after surgery. At the time of the deceased donor kidney transplant, participants will be randomly assigned to received a kidney that has been treated with either C1INH or a…
The goal of this clinical trial is to learn if an investigational medication called siplizumab can prevent rejection of a kidney transplant patients with end stage kidney disease. The study will compare two different doses of siplizumab to a medication that is standardly used post kidney transplant to prevent rejection, rabbit anti-thymocyte globulin (rATG…
This is a Phase 1 trial testing two experimental vaccines for HIV called DV700P-RNA and DV701B1.1-RNA. This study is testing whether these vaccines are safe to use in people living with HIV and if they can be taken comfortably, as well as how the immune system responds to the vaccines. Both vaccines are made using messenger ribonucleic acid (mRNA)…
The purpose of this study is to assess the safety of the Investigational study drug called BNT351 and get information about how well it works for HIV. BNT351 is currently being tested in humans and is the first time the study drug will be given to people. It is not FDA approved yet. You will be invited to take part if you are 18 to 65 years of age in good…
This study is testing whether a new investigational medicine called frexalimab can safely and effectively prevent kidney transplant rejection compared to tacrolimus, a standard medication currently used after transplant. Participants will be randomly assigned to receive either frexalimab (given by injection every 4 weeks) or tacrolimus (taken as capsules…
The main goal of this clinical trial is to determine if an investigational medication called VEL101 is safe, well tolerated, and effective in people receiving a new kidney transplant. Participants will be randomly assigned to 2 different doses of VEL-101 or to tacrolimus, which is standardly used post-transplant to prevent rejection. Participants will be…
Thank you for your interest in our research! We are studying how life experiences impact brain health and memory in people with and without HIV. Your participation can help advance science and improve future care. What's involved? You'll come to the Columbia University Irving Medical Center for a one-time visit, which includes a blood draw, urine…
The primary objective is to determine whether using hearts from HIV+ donors for HIV+ recipients is safe with regard to major transplant-related and HIV-related complications. The primary outcome is patient survival at one year. If you have any questions regarding this study, please contact the Transplant Clinical Research Center (TCRC).
We are looking for individuals 18 to 65 years old who are interested in learning more about HIV prevention and biomedical research studies. We will ask you to complete a brief questionnaire to find out if we can schedule you for a one-on-one, 1.5-hour education visit to learn about the research we do. The education visit will help you decide if you want to…