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Liquid biopsy and radiomics for liver cancer surveillance

Condition: Cancer / Liver Cancer

Status: Currently Recruiting

This study aims to use new technology involving molecular and imaging tests to help detect liver cancer early in patients. Participants enrolled will participate in it for approximately 5 years. The purpose of this study is to determine if an experimental drug, INT-787, is safe and effective in patients who are hospitalized due to severe alcohol-associated…

Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature (ELEGANCE)

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sahil Parikh, MD

Status: Currently Recruiting

This study aims to collect information about the symptoms and treatments of patients who have severely clogged arteries and are treated with commercially available Boston Scientific Corporation drug-eluting devices marketed for the treatment of lesions located in the peripheral vasculature. Participation in the study is expected to last for up to two (2)…

Study of Atezolizumab and Bevacizumab Alone or in Combination with Tiragolumab in Patients with Hepatocellular Carcinoma (HCC)

Condition: Cancer / Liver Cancer

Investigator: Linda Wu, MD

Status: Closed

The purpose of this study is to compare the effects, good or bad, of tiragolumab plus atezolizumab plus bevacizumab versus placebo plus atezolizumab plus bevacizumab on patients with HCC. In this study, participants will be randomized you will get either tiragolumab plus atezolizumab plus bevacizumab or placebo plus atezolizumab plus bevacizumab. A placebo…

Observational Study to Assess Transradial Access for Treatment in the Lower Extremities (R2P Registry)

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sanjum Sethi, MD, MPH

Status: Closed

This is a prospective, multi-center, observational, post-market study that will evaluate the safety and procedural success of performing trans-radial access for treatment of atherosclerotic lesions in the lower extremities. This research study will collect outcome data of patients undergoing percutaneous endovascular treatment of Peripheral Artery Disease (…

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Condition: Cancer / Liver Cancer

Investigator: Yvonne Saenger, MD

Status: Closed

The purpose of this study is to learn more about TPST-1120. The aims of the study are to find out if TPST-1120 can be given safely to people, to determine a safe dose of the study drug, if it is safe when given in combination with other anti-cancer drugs, what effects the drug may have, and to learn more about how the body processes the study drug. This is…

TAP-DANCE: Temsirolimus Alone or Paired with Dexamethasone After Femoropopliteal Revascularization (Femoral Artery Disease Procedure)

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sahil Parikh, MD

Status: Closed

This study is to test if a combination drug/device therapy using TEMSIROLIMUS (Temsirolimus Injection), with or without the generic steroid DEXAMETHASONE (Dexamethasone Sodium Phosphate Injection), can be delivered safely into the tissue around the blood vessel wall at the time of an angioplasty ( which is a a procedure to open blocked arteries and restore…

A 5-Year Study of the Natural History and Management of Patients with Hepatocellular Carcioma (A Type of Liver Cancer)

Condition: Cancer / Liver Cancer

Investigator: Elizabeth Verna, MD

Status: Closed

Patients will be asked to participate in this research study because they have been diagnosed with hepatocellular carcinoma (HCC) which is a type of liver cancer. By doing this study, researchers hope to: Find out more about patients that have HCC including their age, race/ethnicity, and other medical conditions they may have; learn more about how…

A study of the safety and effectiveness of a new drug coated balloon in blockages above the knee.

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sahil Parikh, MD

Status: Closed

The purpose of this study is to deterimine if the Drug-Coated Chocolate Touch Balloon Catheters is safe and effective compared to a drug-coated balloon that is already approved in patients with a blockage in the blood vessels of their leg.

Comparison of a device that delivers sonic energy (sound) versus standard balloon to disrupt hard, calcified vascular blockages

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sahil Parikh, MD

Status: Closed

This study is for patients who suffer from a condition where one of the blood vessels that deliver blood to your leg has a significant narrowing. This is called peripheral artery disease (PAD). The narrowing may be suitable for a treatment technique called balloon angioplasty. One of the therapies that has been used to treat PAD is balloon angioplasty. It…

Ponatinib in Advanced or Metastatic Medullary Thyroid Cancer

Condition: Cancer / Thyroid Cancer

Investigator: Antonio Fojo, MD, PhD

Status: Closed

This is a study designed for patients with medullary thyroid cancer. Treatment will consist of a drug called Ponatinib. Ponatinib is an investigational agent that blocks abnormal cancer proteins and therefore harms cancer cells. It was recently approved by the Food and Drug Administration for leukemia treatment, but is not approved for medullary thyroid…

SCOPE CLI: Shifting Care and Outcomes for Patients With Endangered Limbs - Critical Limb Ischemia

Condition: Heart Disease / Peripheral Arterial Disease

Investigator: Sahil Parikh, MD

Status: Closed

This study is to collect information about the symptoms and treatments of patient who have severely clogged arteries and to learn about their outcomes at one year. If you choose to be part of this research, we will ask you to be involved in five interviews with study staff. Each interview will take about 30 minutes of your time and we will contact you…

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