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Displaying 1 - 12 of 12

Assess Treatments for Painful Diabetic Peripheral Neuropathy (PDPN)

Condition: Diabetes
Investigator: Thomas Brannagan, MD
Status: Closed
The purpose of this study is to Assess Treatments for Painful Diabetic Peripheral Neuropathy (PDPN). To be in this study you must have type II Diabetes Mellitus, PDPN, must be 18 years of age or older, and be able to stop taking some of your current pain medications including pills, creams, patches, marijuana, cannabidiol (CBD) oil, etc. Acetaminophen (…
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Time Restricted EATing (TREAT) to Improve Cardiometabolic Health

Condition: Diabetes
Investigator: Blandine Laferrere, MD, PhD
Status: Closed
This is a randomized trial that will examine the effect of self-monitoring food intake via a smartphone application, and of a novel lifestyle intervention called time-restricted eating, on improvement of metabolic health in persons with overweight or obesity. The intervention lasts 12 months and will be administered via a smartphone app. Participants will…
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Study in Patients With Diabetic Peripheral Neuropathic Pain (DPNP) (PROGRESS)

Condition: Diabetes
Investigator: Thomas Brannagan, MD
Status: Closed
To be in this study you must have Diabetic Peripheral Neuropathic (DPN) and be 18 years of age, inclusive, with the presence of bilateral pain in lower extremities due to DPN for at least 6 months prior to Screening and be in a stable regimen for the treatment of T1DM or T2DM for 3 months prior to Screening.
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Pancreatic Clamp Study: Lowering Insulin Levels During Temporary Insulin Resistance

Condition: Diabetes
Investigator: Joshua Cook, MD, PhD
Status: Closed
We're conducting a research study on how much insulin is needed to control blood sugar in people who are made temporarily resistant to insulin's effects. Insulin is the main hormone (chemical signal) that the body uses to lower the levels of sugar in the blood. We are interested in looking at insulin levels because we think that lowering insulin…
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Investigating Problem Solving in Health Management

Condition: Diabetes
Investigator: Lena Mamykina, PhD
Status: Closed
We are conducting an academic study to understand how people solve problems related to health. In the study, participants will be presented with a hypothetical problem related to diabetes self-management and asked to use an online health application to explore information and propose a solution. We invite all participants between 18 and 65 years old, who…
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Rest-Activity Rhythms and Blood Pressure

Condition: Diabetes
Investigator: Nour Makarem, PhD
Status: Closed
We are currently looking for men and non-pregnant women aged 40 years and above to participate in an at-home study on sleep and activity patterns in relation to blood pressure and blood glucose. Participants should not have critical/severe illness and should not be on dialysis or have a pacemaker or other implanted medical device. You must be willing to…
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Temporary Insulin Resistance

Condition: Diabetes
Investigator: Joshua Cook, MD, PhD
Status: Closed
We are recruiting healthy volunteers, aged 18-65, for a research study on the buildup of excessive liver fat ("fatty liver disease") in people with or at risk for type 2 diabetes because their bodies are resistant to the actions of the blood sugar-lowering hormone, insulin. To do this, we seek to induce temporary insulin resistance in 10-12…
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Study of New Drug (VX-548) in Patients with Painful Diabetic Peripheral Neuropathy

Condition: Diabetes
Investigator: Thomas Brannagan, MD
Status: Closed
The purpose of this study is to evaluate the safety, tolerability, and effectiveness of VX-548 in participants with pain due to Diabetic Peripheral Neuropathy (DPN). To be in this study you must have DPN and be 18 through 80 years of age, inclusive, with presence of bilateral pain in lower extremities due to DPN for at least 1 year.
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Effect of Lowering Insulin Levels on Blood Sugar

Condition: Diabetes
Investigator: Joshua Cook, MD, PhD
Status: Closed
We are conducting a research study on how much insulin is needed to control blood sugar in people at risk for type 2 diabetes. We are seeking adult volunteers, aged 18-65, who are overweight or obese with a body mass index of 25.0-39.9 and have been diagnosed with or are at risk for prediabetes. Participants will undergo two pancreatic clamp procedures…
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Denosumab to Strengthen Bones of Women with Diabetes

Condition: Diabetes
Investigator: Mishaela Rubin, MD
Status: Closed
The purpose of this research study is to learn more about bone strength in women with type 2 diabetes, and to find out whether an experimental drug called Denosumab may help preserve bone strength. Type 2 Diabetes Mellitus (T2DM) has become one of the most important diseases of our time. Recent research shows that diabetes has negative effects on bones and…
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Phone Interview for Latinas and Black Women with Type 2 Diabetes (Ages 18-40)

Condition: Diabetes
Investigator: Maureen George, PhD, RN, AE-C, FAAN
Status: Closed
The purpose of this study is to find out how Black and Latina women with type 2 diabetes prefer to learn about getting healthy before pregnancy. Participation will involve a conversation for 1-2 hours. We will ask questions and get your thoughts on your health, your diabetes, pregnancy, and birth control. We have prepared some questions, but will be…
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Vitamin B6 to Strengthen Bones of Women with Type 2 Diabetes

Condition: Diabetes
Investigator: Mishaela Rubin, MD
Status: Closed
The purpose of this study is to determine if a specific form of Vitamin B known as pyridoxamine helps improve bone strength over one year in women (65 yrs old) with Type 2 Diabetes. We know that people with type 2 diabetes have the lower bone material strength and we suspect this is due to high levels of circulating sugars that build up over time (known as…
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