The purpose of this study is to understand how liverdisease affects thinking and memory, both before and after transplant. Participants will take a cognitive test, which will be a series of tasks and questions similar to a video game, at home on their own computers, tablets, or phones. This will…
The main purpose of this study is to deeply characterize cognitive function in liver transplant recipients, differentiate among different causes of cognitive impairment, and identify contributors to cognitive impairment. Participants will receive a comprehensive neurological exam, cognitive assessment, neuropsychological…
We are conducting a research study on the effect of high insulin levels on the buildup of excessive liver fat ("fatty liverdisease") in people at risk for type 2 diabetes. We are seeking adult volunteers, ages 18-65, who have obesity with a body mass index of 30-45…
The purpose of this study is to learn more about the effects of functional status (also known as "frailty") using a physical test in patients with liverdisease on their health outcomes. We are enrolling patients prior to liver transplantation, and will continue to…
The purpose of this observational research study is to identify things that contribute to outcomes in patients with alcohol-associated liverdisease who are being considered for liver transplant and who have less than 6 months of sobriety. We will look at many…
This is a prospective, randomized, multi-center, controlled study for subjects with end stage liverdisease who require a liver transplant, comparing whole liver preservation via hypothermic machine perfusion (HMP) using the LLT System…
The purpose of this study is to evaluate the safety of siplizumab when used as induction immunosuppression in patients with primary sclerosing cholangitis or autoimmune hepatitis undergoing liver transplantation. Induction immunosuppression drugs are very potent anti-rejection drugs that are given immediately after…
Polycystic ovary syndrome (PCOS) is a common disorder. Young women with PCOS have irregular or absence of menstruation and excessive acne and or hair on their bodies. They may have multiple cysts on their ovaries. Adolescents and women affected with PCOS are at risk of developing abnormalities in their blood including high fat, low HDL cholesterol (good…
We are recruiting healthy volunteers, aged 18-65, for a research study on the buildup of excessive liver fat ("fatty liverdisease") in people with or at risk for type 2 diabetes because their bodies are resistant to the actions of the blood sugar-lowering hormone,…